[HSF] More Bad News About Trasylol

[prasannasimha]

Thanks.
Incidentally whatever "renal failure" that I have seen when Aprotinin 
has been used has been more often reversible and mainly increased 
creatinine managed conservatively and sometimes with peritoneal 
dialysis. Nothing leading to ESRD.
Prasanna

Ben Bidstrup wrote:
> Prasanna,
> Here they are.
>
> 1.    Koch, C.G., et al., Transfusion in coronary artery bypass 
> grafting is associated with reduced long-term survival. Ann Thorac 
> Surg, 2006. 81(5): p. 1650-7.
>
> 2.    Koch, C.G., et al., Morbidity and mortality risk associated with 
> red blood cell and blood-component transfusion in isolated coronary 
> artery bypass grafting. Crit Care Med, 2006. 34(6): p. 1608-16.
>
> 3.    Koch, C.G., et al., Persistent effect of red cell transfusion on 
> health-related quality of life after cardiac surgery. Ann Thorac Surg, 
> 2006. 82(1): p. 13-20.
>
> There is also one from UK last year.
>
> Kuduvalli, M., et al., Effect of peri-operative red blood cell 
> transfusion on 30-day and 1-year mortality following coronary artery 
> bypass surgery. Eur J Cardiothorac Surg, 2005. 27(4): p. 592-8.
>
>
>> Ah Michael I  had a feeling you will jump in !! Can you give the 
>> Cleveland clinic quote - (wrt to the 7 % blood transfusion risk) -I 
>> cannot seem to get hold of it.
>> Dr Levinson, I still feel pdf files should be allowed. I think that 
>> copyright laws still allow us too circulate them privately for 
>> educational prurposes. This is freely done in the critical care list 
>> and Gas net (the Anesthesiologists list). In fact now many journals 
>> allow open access after say 6 months to a year after publications.
>> Prasanna
>> Michael Firstenberg wrote:
>>> Hal,
>>> Since I am always on the other side of your coin.  What about all of 
>>> the risks of blood transfusions?  There is plenty of data that 
>>> relates blood product usage to increased risk of adverse outcomes. 
>>> How do you respond to the Catfish type that say - "if you had used 
>>> aprotinin/amicar/etc then my client would not have gotten ......"?
>>>
>>> Michael
>>>
>>> for my Bentall - give me Amicar.
>>> for my redo infected Bentall - hmmm, might take the risk......
>>>
>>>
>>> On Sep 30, 2006, at 2:17 PM, Hgrmd at aol.com wrote:
>>>
>>>> Prasanna,
>>>>   We haven't heard from Claudia, our in house hematologist, in  
>>>> awhile.
>>>> Perhaps she can comment.  However, my impression is that the blood 
>>>> bank, at least
>>>> in the U.S., is about as safe as it has ever been.  I  agree that 
>>>> new blood
>>>> borne diseases may arise in the future, but the risk of 
>>>> aprotinin-associated
>>>> ATN is immediate and real.
>>>> Hal
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