[HSF] More Bad News About Trasylol

[Hgrmd at aol.com]

Prasanna,
  I'm glad you've never seen permanent ESRD with aprotinin--I  have.  In 
fact, what tipped me off many years ago that aprotinin produced  ATN was a 
completely uneventful, easy AVR that I did on an old lady receiving  aprotinin.  
After she went on the pump, she never made a drop of urine,  absolutely zero.  
Otherwise, she did OK, but she ended up on permanent  HD.  I had never even heard 
of aprotinin-associated ATN, but this  definitely made me suspicious. Most of 
the aprotinin-associated ATN does  resolve, but some does not.  As we all 
know, ATN with dialysis requires  invasive lines that can get infected.  
Antibiotics can lead to C.  dif.  Etc, etc.  
Hal