[HSF] Allopurinol

[prasannasimha]

Er, Dr Salerno, the issue here was not ischemia reperfusion but CPB 
mediated inflammatory response- the kidneys are usually perfused when we 
are on CPB (at least we hope so) except during TCA. I think most remal 
injury on CPB may be related to a large extent to the shunting of 
cortical flow to the medulla in kidneys when we perfuse. I think TRT may 
at the best attenuate some of that response by producing more uniform 
reno vasodilatation at the best.
Prasanna
Salerno, Tomas wrote:
> best treatment for ischemia-reperfusion injury is prevention.... the only method todate is perfusion
>  
> Tomas
>
> ________________________________
>
> From: openheart-l-bounces at lists.hsforum.com on behalf of prasannasimha
> Sent: Sun 1/21/2007 8:41 PM
> To: OpenHeart-L at lists.hsforum.com
> Subject: Re: [HSF] Allopurinol
>
>
>
> Hal there were some studies documenting its efficacy in children and
> mostly lambs and pigs. How much of it could be extended to human adults
> is  a bit of the problem. As I said there is some literature and I will
> dig it out (Bit busy today so will do it when I have the time)
> Prasanna
> Hgrmd at aol.com wrote:
>   
>> Dear Sherman,
>>   Where is the clinical evidence that allopurinol is of any benefit in 
>> treating intraop myocardial damage?  I assume it theoretically diminishes 
>> reperfusion damage.  Again, in the absence of blinded, randomized studies,  how do you
>> know it does anything?
>> Hal
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