[HSF] To Treat the Dead

[Donald Ross]

Tea,
This is very interesting and dovetails with recent interest in the  
fact that the mitachondria are turned off in cancer cells which  
exclusively use anaerobic metabolism. A drug which turns the  
mitachondria back on so they can get on with apoptosis has had some  
success in regressing  tumours in rats.
The scenario of a LM closure with   global ischaemia which is a  
notorious difficult to fix may be an area where our management could  
be changed by say, perfusing retrograde with cold saline and delaying  
the opening of grafts for ????? how long.
Don

PS "aborting apoptosis" is a lovely catch cry which would horrify BWB

On 02/05/2007, at 9:24 AM, Tea Acuff wrote:

> I wondered it anyone has been doing any study in this space...the  
> putative dead. Some of this would make sense with the gap I am  
> seeing on cardiac MR between live but "hybernating" muscle that  
> responds (eventually) to revascularization and old scar. The stuff  
> in the gap is thinned out muscle without scarrring, which is what  
> one expect to see if apoptosis is the cause.  I don't think this  
> article is referring to the anoxic brain, but maybe that is a space  
> for work also.
> Tomas, any comments on the heart?
> tea
>
> See article below:
> http://www.msnbc.msn.com/id/18368186/site/newsweek?GT1=9951
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