[HSF] To Treat the Dead(OT)

[Donald Ross]

No Tea; it was meant to be JWB, a three letter acronym I  am sure you  
will recognise.

On 03/05/2007, at 9:50 AM, Tea Acuff wrote:

> Aborting apoptosis sounds like a modern French novel...
>
> BWB...is that Ben Bistrup better known just as "W"?
>
>
> ----- Original Message ----
> From: Donald Ross <donross at bigpond.com>
> To: OpenHeart-L at lists.hsforum.com
> Sent: Wednesday, May 2, 2007 4:11:50 AM
> Subject: Re: [HSF] To Treat the Dead
>
>
> Tea,
> This is very interesting and dovetails with recent interest in the
> fact that the mitachondria are turned off in cancer cells which
> exclusively use anaerobic metabolism. A drug which turns the
> mitachondria back on so they can get on with apoptosis has had some
> success in regressing  tumours in rats.
> The scenario of a LM closure with   global ischaemia which is a
> notorious difficult to fix may be an area where our management could
> be changed by say, perfusing retrograde with cold saline and delaying
> the opening of grafts for ????? how long.
> Don
>
> PS "aborting apoptosis" is a lovely catch cry which would horrify BWB
>
> On 02/05/2007, at 9:24 AM, Tea Acuff wrote:
>
>> I wondered it anyone has been doing any study in this space...the
>> putative dead. Some of this would make sense with the gap I am
>> seeing on cardiac MR between live but "hybernating" muscle that
>> responds (eventually) to revascularization and old scar. The stuff
>> in the gap is thinned out muscle without scarrring, which is what
>> one expect to see if apoptosis is the cause.  I don't think this
>> article is referring to the anoxic brain, but maybe that is a space
>> for work also.
>> Tomas, any comments on the heart?
>> tea
>>
>> See article below:
>> http://www.msnbc.msn.com/id/18368186/site/newsweek?GT1=9951
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