[HSF] To Treat the Dead(OT)

[Ben Bidstrup]

Not me,   mine is P.

>Aborting apoptosis sounds like a modern French novel...
>
>BWB...is that Ben Bistrup better known just as "W"?
>
>
>----- Original Message ----
>From: Donald Ross <donross at bigpond.com>
>To: OpenHeart-L at lists.hsforum.com
>Sent: Wednesday, May 2, 2007 4:11:50 AM
>Subject: Re: [HSF] To Treat the Dead
>
>
>Tea,
>This is very interesting and dovetails with recent interest in the 
>fact that the mitachondria are turned off in cancer cells which 
>exclusively use anaerobic metabolism. A drug which turns the 
>mitachondria back on so they can get on with apoptosis has had some 
>success in regressing  tumours in rats.
>The scenario of a LM closure with   global ischaemia which is a 
>notorious difficult to fix may be an area where our management could 
>be changed by say, perfusing retrograde with cold saline and delaying 
>the opening of grafts for ????? how long.
>Don
>
>PS "aborting apoptosis" is a lovely catch cry which would horrify BWB
>
>On 02/05/2007, at 9:24 AM, Tea Acuff wrote:
>
>>  I wondered it anyone has been doing any study in this space...the 
>>  putative dead. Some of this would make sense with the gap I am 
>>  seeing on cardiac MR between live but "hybernating" muscle that 
>>  responds (eventually) to revascularization and old scar. The stuff 
>>  in the gap is thinned out muscle without scarrring, which is what 
>>  one expect to see if apoptosis is the cause.  I don't think this 
>>  article is referring to the anoxic brain, but maybe that is a space 
>>  for work also.
>>  Tomas, any comments on the heart?
>>  tea
>>
>>  See article below:
>>  http://www.msnbc.msn.com/id/18368186/site/newsweek?GT1=9951
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-- 
Ben Bidstrup FRACS FRCSEd FEBCTS
Consultant Cardiothoracic Surgeon